Liquid may be useful in patients unable or unwilling to swallow large tablets daily, but only if there are two types of demonstration of the drug.

Metformin tablets: liquid and common medication and, in the case of type 2 diabetes

Metformin is the conventional oral diabetes Type 2 in the first row of medication for obese patients who fail to comply with in order to achieve an adequate level of blood sugar management, diet and physical activity. Large 500 mg or 850 mg tablets may be difficult to swallow, in particular, for people who are concerned about when swallowing pills and Metformin is often high in the context of the daily dose.Liquid metformin allows easy to swallow, but it is the equivalent to that of the bioavailability of tablets?

Metformin Pharmacokinetics Study

Metformin pharmacokinetics studies show that it is to remove the body very quickly munuaistiehyeiden. it will hardly karbendatsiimiksi and binding plasma proteins to negligible levels. At the same time as the gut its absorption is slow. The active ingredient of the bioavailability of the drug, therefore, requires multiple, often dosing.

 Bioequivalence of liquid metformin and tablets

There is evidence that metformin in liquid form is exactly the type of item to a form with a Tablet PC. Trial, on the basis of a comparison of 500 mg tablet, 850 mg Tablet-PC, liquid metformin 850 mg dose administration, all the food, not showed a substantial difference bioavailability or the timing of peak blood concentration.

Metformin medication for the improvement of the bioavailability of diabetes

Although differences bioavailability has been found between metformin tablets or liquid, 14% higher bioavailability was detected in patients who took 500 mg in a Tablet PC that is 850 mg, as compared to the Tablet-PC.In addition, bioavailability was almost 25% lower when the tablets were to come into contact with foodstuffs.Metformin in the peak blood concentration was delayed for more than 35 minutes also patients who swallowed the Tablet PC with the meal.

As you type 2 diabetes patients taking metformin medication may experience unpleasant adverse gastrointestinal irritation, if they had to swallow tablets, when eating. studies will be needed, but if it should be possible while taking metformin patients can tolerate without food, this could significantly increase the bioavailability.Whether the metformin in liquid form occur more easily, than the tablets in these circumstances also require further investigation.